Endocrine Abstracts

Androgen receptor (AR) signaling is critical at all stages of prostate cancer including chemically castrated late-stage forms of the disease. How the AR can initiate transcription in the absence of androgens has been proposed to occur through several mechanisms including the production of constitutively active androgen receptor variants. Lacking a ligand binding domain, these variants are intrinsically resistant to all clinically approved AR antagonists and have been found to ...

Introduction: Wegener granulomatosis is a necrotizing granulomatous small-vessel vasculitis. It typically affects the upper respiratory tract, lungs, and kidneys but can involve virtually any organ including the pituitary. Pituitary involvement in wegener granumatosis is rare.Case: A 50-year-old woman was admitted to the hospital with severe dyspne for 2 years and stridor for a month. During her hospitalization, her sodium level was noted to be persisten...

Objective: Thyroid hormones are powerful mediators of numerous physiological and metabolic processes, including blood clotting, and thyroid dysfunction can adversely affect various stages in the coagulation cascade. Mean platelet volume (MPV) is used to measure platelet size and may indicate platelet activity. Studies have reported that increased MPV is associated with atherosclerotic lesions and cardiovascular diseases, and conflicting results have been reported for the relat...